3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one

Base Information

Chemical Name:3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one
CAS No.:216970-84-2
Molecular Formula:C₁₉H₁₅F₃N₂O₅S
Molecular Weight:440.4
Hs Code.:

Synonyms:3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one

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Chemical Property of 3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one

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Technology Process of 3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one

There total 10 articles about 3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 216970-82-0
3-(4-methoxyphenyl)-6-(4-pyridyl)-3-hydroxy-1-methyl-1H-pyridin-2-one

: 216970-84-2
3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one

Guidance literature:: In pyridine; dichloromethane; at -78 - 0 ℃;
DOI:10.1016/S0040-4039(99)00651-6

Reference yield:

: 40061-24-3
2-(4-methoxyphenyl)-1-(4-pyridyl)ethan-1-one

: 216970-84-2
3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: TiCl₄ / CH₂Cl₂ / 18 h / 20 °C

2.1: tetrahydrofuran / 1.5 h / 0 °C

3.1: POCl₃ / CH₂Cl₂ / 2.5 h / 20 - 75 °C

3.2: 28 percent / NaOH / tetrahydrofuran / pH 9 - 10

4.1: 75 percent / HCO₂NH₄; AcOH / 10percent Pd/C / methanol / 3.5 h / 20 °C

5.1: pyridine / CH₂Cl₂ / 1 h / -78 °C

With pyridine; ammonium formate; titanium tetrachloride; acetic acid; trichlorophosphate; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; 3.1: Vilsmeier formylation / 3.2: Meth-Cohn cyclization;
DOI:10.1021/jm0110789

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 216970-84-2
3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 1.5 h / 20 °C

2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C

2.2: 42 percent / tetrahydrofuran / -78 - 20 °C

3.1: 87 percent / aq. NaCl / dimethylsulfoxide / 2 h / 150 °C

4.1: TiCl₄ / CH₂Cl₂ / 18 h / 20 °C

5.1: tetrahydrofuran / 1.5 h / 0 °C

6.1: POCl₃ / CH₂Cl₂ / 2.5 h / 20 - 75 °C

6.2: 28 percent / NaOH / tetrahydrofuran / pH 9 - 10

7.1: 75 percent / HCO₂NH₄; AcOH / 10percent Pd/C / methanol / 3.5 h / 20 °C

8.1: pyridine / CH₂Cl₂ / 1 h / -78 °C

With pyridine; ammonium formate; titanium tetrachloride; acetic acid; sodium chloride; lithium diisopropyl amide; trichlorophosphate; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 2.2: Claisen condensation / 3.1: Krapcho,s decarboxylation / 6.1: Vilsmeier formylation / 6.2: Meth-Cohn cyclization;
DOI:10.1021/jm0110789