2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride

Base Information

Chemical Name:2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride
CAS No.:1606974-31-5
Molecular Formula:C₂₂H₂₁ClN₂O*ClH
Molecular Weight:401.335
Hs Code.:

Synonyms:2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride

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Chemical Property of 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride

Chemical Property:

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Technology Process of 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride

There total 5 articles about 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1606977-00-7
2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol

: 1606974-31-5
2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 1606976-97-9
4-chloro-2-(3-chlorophenyl)-6-cyclopropylpyridine

: 1606974-31-5
2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 2 h / 120 °C / Microwave irradiation; Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 50 °C

3: hydrogenchloride / methanol

With hydrogenchloride; dimethylsulfide borane complex; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 16063-69-7
2,4,6-trichloropyridine

: 1606974-31-5
2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyridin-4-yl)amino)phenyl)ethanol hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 24 h / 90 °C / Inert atmosphere

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 23 h / 90 °C / Inert atmosphere

3: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 2 h / 120 °C / Microwave irradiation; Inert atmosphere

4: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 50 °C

5: hydrogenchloride / methanol

With hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; toluene;