1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

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Chemical Name:1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole
CAS No.:1057662-54-0
Molecular Formula:C₂₀H₂₁F₄N₃O
Molecular Weight:395.4
Hs Code.:

Synonyms:1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

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Chemical Property of 1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

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Technology Process of 1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

There total 2 articles about 1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1022931-92-5
2-(4-bromo-2-fluorophenyl)-1-(pyrrolidin-1-yl)ethan-1-one

: 890005-22-8,35179-55-6
3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

: 1057662-54-0
1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Guidance literature:: 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole; With potassium carbonate; copper(l) iodide; In dimethyl sulfoxide; for 0.0166667h;

2-(4-bromo-2-fluorophenyl)-1-(pyrrolidin-1-yl)ethan-1-one; dimethylaminoacetic acid; In dimethyl sulfoxide; at 180 ℃; for 0.666667h; microwave irradiation; sealed tube;

Reference yield:

: 114897-92-6
2-(4-bromo-2-fluoro-phenyl)acetic acid

: 1057662-54-0
1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; trans-1,2-Diaminocyclohexane; potassium carbonate / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

With copper(l) iodide; trans-1,2-Diaminocyclohexane; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 2.1: Ullmann reaction;
DOI:10.1021/jm100679e