Technology Process of 2,6-dimethylphenyl (2R,3R,4S,5S,6S)-3,5,7-trihydroxy-2,4,6-trimethylheptanoate
There total 15 articles about 2,6-dimethylphenyl (2R,3R,4S,5S,6S)-3,5,7-trihydroxy-2,4,6-trimethylheptanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran;
for 2.5h;
Ambient temperature;
DOI:10.1002/hlca.19900730821
- Guidance literature:
-
Multi-step reaction with 13 steps
1: Amberlyst 15 / methanol / 68 h
2: 96 percent / LiAlH4 / diethyl ether / a) -20 deg C, 3 h, b) r.t., 1.5 h
3: 1) 55percent NaH, 2) Et4NI / 1) hexane, DMF, r.t., 1 h, 2) r.t., 16 h
4: 92 percent / conc. HCl / tetrahydrofuran / 6 h / Ambient temperature
5: 94 percent / imidazole, 4 Angstroem molecular sieves / dimethylformamide / 23 h / Ambient temperature
7: 53 percent / Zn(BH4)2 / diethyl ether / 7 h / -78 °C
8: 93 percent / H2 / 10percent Pd/C / ethyl acetate / 7 h / Ambient temperature
9: 92 percent / camphorsulfonic acid / 6 h / Ambient temperature
10: 99 percent / Bu4NF / tetrahydrofuran / 16 h / Ambient temperature
12: (i-Pr)2NH / tetrahydrofuran / 1 h / -78 °C
13: 67 percent / conc. HCl / tetrahydrofuran / 2.5 h / Ambient temperature
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; Amberlyst 15; zinc(II) tetrahydroborate; 4 A molecular sieve; camphor-10-sulfonic acid; tetraethylammonium iodide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19900730821
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 96 percent / LiAlH4 / diethyl ether / a) -20 deg C, 3 h, b) r.t., 1.5 h
2: 1) 55percent NaH, 2) Et4NI / 1) hexane, DMF, r.t., 1 h, 2) r.t., 16 h
3: 92 percent / conc. HCl / tetrahydrofuran / 6 h / Ambient temperature
4: 94 percent / imidazole, 4 Angstroem molecular sieves / dimethylformamide / 23 h / Ambient temperature
6: 53 percent / Zn(BH4)2 / diethyl ether / 7 h / -78 °C
7: 93 percent / H2 / 10percent Pd/C / ethyl acetate / 7 h / Ambient temperature
8: 92 percent / camphorsulfonic acid / 6 h / Ambient temperature
9: 99 percent / Bu4NF / tetrahydrofuran / 16 h / Ambient temperature
11: (i-Pr)2NH / tetrahydrofuran / 1 h / -78 °C
12: 67 percent / conc. HCl / tetrahydrofuran / 2.5 h / Ambient temperature
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; zinc(II) tetrahydroborate; 4 A molecular sieve; camphor-10-sulfonic acid; tetraethylammonium iodide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19900730821
