Technology Process of (E)-4-cyclohexyl-1,1,1-trifluoro-3-buten-1-one
There total 6 articles about (E)-4-cyclohexyl-1,1,1-trifluoro-3-buten-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate;
In
dichloromethane;
for 48h;
Reflux;
DOI:10.1002/ejoc.201300392
- Guidance literature:
-
With
sulfuric acid;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 1h;
DOI:10.1021/jo048682m
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 °C / Inert atmosphere
2.1: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; silica gel / dichloromethane / 24 h / 20 °C / Sealed tube
3.1: tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
3.2: 6 h / 20 °C
4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
5.1: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; 2,6-dimethylpyridine / dichloromethane / 48 h / Reflux
With
2,6-dimethylpyridine; lithium aluminium tetrahydride; silica gel; Dess-Martin periodane; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/ejoc.201300392
