N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide

Base Information

Chemical Name:N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide
CAS No.:1402581-82-1
Molecular Formula:C₂₃H₂₅ClFN₅O₃S
Molecular Weight:506.001
Hs Code.:

Synonyms:N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide

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Chemical Property of N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide

Chemical Property:

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Technology Process of N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide

There total 10 articles about N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402586-79-1
C₂₈H₃₃ClFN₅O₅S

: 1402581-82-1
N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 4h;

Reference yield:

: (±)-2-(3-fluoro-4-nitrophenyl)propanoic acid

: 1402581-82-1
N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 15 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 6 h

3.1: sodium nitrite; toluene-4-sulfonic acid; potassium iodide / water; acetonitrile / 4.17 h / 10 - 20 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 15 h / 120 °C / Inert atmosphere

5.1: water; sodium hydroxide / tetrahydrofuran / 15 h / 23 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 23 °C

7.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

7.2: 2 h

8.1: triethylamine / dichloromethane / 15 h / 23 °C

9.1: trifluoroacetic acid / dichloromethane / 4 h / 23 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel(II) chloride hexahydrate; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium iodide; sodium hydroxide; zinc; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

Reference yield:

: 95037-98-2
ethyl 2-(4-amino-3-fluorophenyl)propionate

: 1402581-82-1
N-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]propionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium nitrite; toluene-4-sulfonic acid; potassium iodide / water; acetonitrile / 4.17 h / 10 - 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 15 h / 120 °C / Inert atmosphere

3.1: water; sodium hydroxide / tetrahydrofuran / 15 h / 23 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 23 °C

5.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

5.2: 2 h

6.1: triethylamine / dichloromethane / 15 h / 23 °C

7.1: trifluoroacetic acid / dichloromethane / 4 h / 23 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel(II) chloride hexahydrate; water; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium iodide; sodium hydroxide; zinc; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;