7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine

Base Information

Chemical Name:7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine
CAS No.:1614245-82-7
Molecular Formula:C₂₀H₁₈N₄O₂S
Molecular Weight:378.455
Hs Code.:

Synonyms:7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine

Suppliers and Price of 7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine

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Technology Process of 7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine

There total 7 articles about 7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3466-32-8
4-bromoohenyl methyl sulfone

: 1614246-70-6
(3-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)benzene)boronic acid

: 1614245-82-7
7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In water; at 20 - 90 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1268521-56-7
4-chloro-7-ethyl-7H-imidazo[4,5-c]pyridazine

: 1614245-82-7
7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 16 h / Inert atmosphere; Reflux

2: hydrogenchloride / water; tetrahydrofuran / 16 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water / 1.5 h / 20 - 90 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1614246-24-0
5-chloro-N³-ethylpyridazine-3,4-diamine

: 1614245-82-7
7-ethyl-4-[4'-(methylsulfonyl)biphenyl-3-yl]-7H-imidazo[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: 4 h / Reflux

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 16 h / Inert atmosphere; Reflux

3: hydrogenchloride / water; tetrahydrofuran / 16 h / Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water / 1.5 h / 20 - 90 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;