di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate

Base Information

Chemical Name:di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate
CAS No.:679436-30-7
Molecular Formula:C₃₁H₄₃NO₄
Molecular Weight:493.687
Hs Code.:

Synonyms:di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate

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Chemical Property of di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate

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Technology Process of di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate

There total 5 articles about di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 17480-69-2
(S)-N-benzyl-1-phenylethylamine

: 679436-26-1
di-tert-butyl (5S)-5-carboxymethyl-cyclopentene-1-carboxylate

: 679436-30-7
di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate

: 679436-12-5
di-tert-butyl (1S,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate

Guidance literature:: (S)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

di-tert-butyl (5S)-5-carboxymethyl-cyclopentene-1-carboxylate; In tetrahydrofuran; at -78 ℃; for 2h; Further stages.;
DOI:10.1039/b313386a

Reference yield:

: 679436-07-8
(2E,6E)-octa-2,6-diendioic acid di-tert-butyl diester

: 679436-30-7
di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 85 percent / tetrahydrofuran / 2 h / -78 °C

2.1: 86 percent / m-CPBA / CH₂Cl₂ / 24 h / 0 °C

3.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

3.2: 48 percent / tetrahydrofuran / 2 h / -78 °C

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b313386a

Reference yield:

: di-tert-butyl 5-carboxymethyl-cyclopentene-1-carboxylate

: 679436-30-7
di-tert-butyl (1R,2S,5S,αS)-2-N-benzyl-N-α-methylbenzylamino-5-carboxymethyl-cyclopentane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 18 percent / tetrahydrofuran / 2 h / -78 °C

2.1: m-CPBA / CH₂Cl₂ / 24 h / 0 °C

3.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

3.2: 48 percent / tetrahydrofuran / 2 h / -78 °C

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b313386a