pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

Base Information

Chemical Name:pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone
CAS No.:1432050-60-6
Molecular Formula:C₁₉H₁₆F₃NO₄
Molecular Weight:379.336
Hs Code.:

Synonyms:pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

Suppliers and Price of pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

There total 4 articles about pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432050-56-0
3-hydroxy-1-[3-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

: 1432050-60-6
pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 20 °C

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -75 °C

3.2: 3.5 h / -75 - 20 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; Dess-Martin periodane; In diethyl ether; hexane; dichloromethane;

Reference yield:

: 1432050-58-2
3-oxo-1-[3-(trifluoromethoxy)phenyl]cyc lobutanecarbonitrile

: 1432050-60-6
pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -75 °C

2.2: 3.5 h / -75 - 20 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; hexane; dichloromethane;

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1432050-60-6
pyridin-2-yl{2-[3-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether; tetrahydrofuran / 1 h / -75 °C

1.2: 1 h / -75 °C

1.3: -75 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

4.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -75 °C

4.2: 3.5 h / -75 - 20 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;