methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine

Base Information

Chemical Name:methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine
CAS No.:1262278-70-5
Molecular Formula:C₁₉H₂₇NO₆
Molecular Weight:365.426
Hs Code.:

Synonyms:methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine

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Chemical Property of methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine

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Technology Process of methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine

There total 1 articles about methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1262278-69-2
methyl O-[trans-3-(benzyloxy)cyclobutyl]-N-(tert-butoxycarbonyl)-L-tyrosine

: 1262278-70-5
methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2012.11.049

Reference yield: 38.0%

: 1262278-70-5
methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine

: 1262278-71-6
methyl N-(tert-butoxycarbonyl)-O-(cis-3-fluorocyclobutyl)-L-tyrosine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.bmc.2012.11.049

Reference yield:

: 1262278-70-5
methyl N-(tert-butoxycarbonyl)-O-(trans-3-hydroxycyclobutyl)-L-tyrosine

: 1262278-72-7
N-(tert-butoxycarbonyl)-O-(cis-3-fluorocyclobutyl)-L-tyrosine

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 0 °C

2: lithium hydroxide / methanol / 6 h / 20 °C

With diethylamino-sulfur trifluoride; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2012.11.049