(5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Base Information

Chemical Name:(5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate
CAS No.:1227685-22-4
Molecular Formula:C₂₀H₂₄N₂O₆
Molecular Weight:388.42
Hs Code.:

Synonyms:(5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Suppliers and Price of (5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate

There total 6 articles about (5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)amino]-2-methylpiperidine-1,4-dicarboxylate

: 1227685-22-4
(5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Guidance literature:: With sodium ethanolate; In methanol; at 20 ℃; for 0.333333h;

Reference yield:

: 1227685-21-3
(2S,4R)-1-benzyl 4-methyl 4-(3-ethoxy-3-oxopropanamido)-2-methylpiperidine-1,4-dicarboxylate

: 1227685-23-5
(5R,7S)-benzyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]-decane-8-carboxylate

: 1227685-22-4
(5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Guidance literature:: With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo400016m

Reference yield:

: 921599-74-8,852051-10-6
benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

: 1227685-22-4
(5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: magnesium chloride; lithium hexamethyldisilazane / 1,2-dimethoxyethane / 4 h / -78 - -20 °C / Inert atmosphere

2: 18-crown-6 ether; sodium azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C / Inert atmosphere; Cooling with ice

3: zinc; acetic acid / tetrahydrofuran / 20 h / 20 - 50 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

5: sodium ethanolate / ethanol / 0.5 h / 20 °C / Inert atmosphere

With sodium azide; 18-crown-6 ether; sodium ethanolate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; magnesium chloride; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; 5: |Dieckmann Condensation;
DOI:10.1021/jo400016m