(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde

Base Information

Chemical Name:(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde
CAS No.:768395-22-8
Molecular Formula:C₂₃H₃₀O₂Si
Molecular Weight:366.576
Hs Code.:

Synonyms:(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde

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Technology Process of (1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde

There total 6 articles about (1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 768395-42-2
[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-methanol

: 768395-22-8
(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1002/anie.200460203

Reference yield:

: 6453-07-2,28269-02-5,28269-03-6,35079-19-7,74500-50-8,115794-30-4
(+/-)-trans-4-oxo-1,2-cyclopentanedicarboxylic acid bis(methyl ester)

: 768395-22-8
(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 49 percent / pig liver esterase; phosphate buffer / H₂O / 1 h / pH 7.0

2: 72 percent / SnCl₄ / CH₂Cl₂ / 8 h / 0 - 25 °C

3: 92 percent / Raney Ni / methanol / 3 h / Heating

4: 92 percent / LiAlH₄ / diethyl ether / 12 h / 25 °C

5: 84 percent / imidazole; DMAP / CH₂Cl₂ / 8 h / 25 °C

6: 89 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 25 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; phosphate buffer; pig liver esterase; tin(IV) chloride; Dess-Martin periodane; nickel; In methanol; diethyl ether; dichloromethane; water; 6: Dess-Martin oxidation;
DOI:10.1002/anie.200460203

Reference yield:

: 35079-19-7
trans-(1R,2R)-1,2-Bis(methoxycarbonyl)-4-oxocyclopentane

: 768395-22-8
(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / SnCl₄ / CH₂Cl₂ / 8 h / 0 - 25 °C

2: 92 percent / Raney Ni / methanol / 3 h / Heating

3: 92 percent / LiAlH₄ / diethyl ether / 12 h / 25 °C

4: 84 percent / imidazole; DMAP / CH₂Cl₂ / 8 h / 25 °C

5: 89 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 25 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; tin(IV) chloride; Dess-Martin periodane; nickel; In methanol; diethyl ether; dichloromethane; 5: Dess-Martin oxidation;
DOI:10.1002/anie.200460203