10.3762/bjoc.8.95
The research presents an in-depth study on the application of two-directional synthesis in diversity-oriented synthesis (DOS), focusing on the rapid construction of complex molecular architectures from simple starting materials, particularly for the synthesis of alkaloid scaffolds. The experiments involved the synthesis of linear precursors, such as N-Boc-aminoalkenes containing α,β-unsaturated ester groups, which were then subjected to intramolecular pairing reactions under various Lewis acid conditions to form bicyclic and tricyclic scaffolds. Reactants included compounds like nitromethane and tris(hydroxymethyl)aminomethane (Tris), and analyses utilized techniques such as NMR spectroscopy, X-ray crystallography, and IR spectroscopy to confirm the structures and stereochemistry of the synthesized compounds. The study also explored the total synthesis of myrrhine and the potential of different substrates like nitromethane and Tris in DOS, demonstrating the versatility and efficiency of two-directional synthesis in generating molecular diversity.
10.1039/c3dt51800k
The research focuses on the synthesis, characterization, and investigation of two novel heterometallic complexes, [Cu2Fe2(HL1)2(H2L1)2]·10DMSO (1) and [Cu2Fe2(HL2)2(H2L2)2]·2DMF (2), which contain a tetranuclear {Cu2Fe2(μ-O)6} core supported by polydentate Schiff base ligands. The study involves the direct synthesis of these complexes using copper powder, iron(II) chloride, and DMSO or DMF solutions of the Schiff bases formed in situ from salicylaldehyde or 5-bromo-salicylaldehyde and tris(hydroxymethyl)aminomethane. The synthesized compounds were analyzed using various techniques, including crystallographic analysis, variable-temperature magnetic susceptibility measurements, high-field EPR spectroscopy, M?ssbauer spectra, and catalytic activity tests in the oxidation of cyclohexane with hydrogen peroxide under mild conditions. The experiments aimed to explore the magnetic properties and exceptional catalytic activity of these complexes, which showed high yields and turnover numbers in the oxidation reactions.
10.1007/s11164-021-04558-9
This research focuses on the synthesis and application of a novel Fe3O4@THAM?CH2CH2?SCH2CO2H magnetic nanocatalyst for the efficient preparation of xanthenes and 3?aminoisoxazoles under green conditions. The purpose is to develop an environmentally friendly and efficient catalytic system that can be easily recovered and reused. The key chemicals used include FeCl3·6H2O, FeCl2·4H2O for synthesizing the Fe3O4 core, tris(hydroxymethyl)aminomethane (THAM) for coating, and thioglycolic acid for functionalization. The nanocatalyst was characterized using various analytical techniques such as FT-IR, TEM, VSM, XRD, TGA, and FE-SEM. The study concludes that this nanocatalyst can significantly reduce reaction times and improve yields while being easily recoverable by an external magnet for up to eight cycles without significant loss of activity. This method is advantageous due to its solvent-free conditions, mild reaction temperatures, and excellent yields, making it a sustainable and economic approach in line with green chemistry principles.
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