Tromethamine

Base Information

• Chemical Name: Tromethamine
• CAS No.: 77-86-1
• Deprecated CAS: 108195-86-4,25149-07-9,68755-45-3,83147-39-1,119320-15-9,857365-23-2,1158650-64-6,1158650-64-6,119320-15-9,68755-45-3,83147-39-1,857365-23-2
• Molecular Formula: C4H11NO3
• Molecular Weight: 121.136
• Hs Code.: 29221980
• European Community (EC) Number: 201-064-4,662-845-7
• NSC Number: 65434,6365
• UNII: 023C2WHX2V
• DSSTox Substance ID: DTXSID2023723
• Nikkaji Number: J4.214E
• Wikidata: Q413961
• NCI Thesaurus Code: C47775
• RXCUI: 10865
• Metabolomics Workbench ID: 71483
• ChEMBL ID: CHEMBL1200391
• Mol file: 77-86-1.mol

Synonyms:Tri(hydroxymethyl)aminomethane;Tris Buffer;Tris(hydroxymethyl)aminomethane;Tris-Magnesium(II)-Potassium Chloride Buffer;Tris-Mg(II)-KCl Buffer;Trisamine;Trizma;Trometamol;Tromethamine

Chemical Property of Tromethamine

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.558mmHg at 25°C
• Melting Point: 167-172 °C(lit.)
• Refractive Index: 1.531
• Boiling Point: 219-220 °C (10 mmHg)
• PKA: 8.1(at 25℃)
• Flash Point: 219-220°C/10mm
• PSA: 86.71000
• Density: 1,353 g/cm3
• LogP: -1.63890
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: H2O: 4 M at 20 °C, clear, colorless
• Water Solubility.: 550 g/L (25 ºC)
• XLogP3: -2.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 121.07389321
• Heavy Atom Count: 8
• Complexity: 54

Purity/Quality:

99.0% ^*data from raw suppliers

Tromethamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39-24/25-23

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Biological Buffers
• Canonical SMILES: C(C(CO)(CO)N)O
• Recent ClinicalTrials: Airway Alkalinization and Nasal Colonization
• Recent EU Clinical Trials: Effects of Tromethamine on Cerebral Oxygenation and Metabolism in Patients Suffering Intractable Intracranial Hypertension – an exploratory study.
• Chemical Properties and Usage: Tromethamine, also known as tris or tris buffer, is an organic amine proton acceptor used in various applications such as surface-active agents, pharmaceuticals, emulsifying agents for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, and as a biological buffer and alkalizer.
• Medical Applications: Tromethamine is used to treat metabolic acidosis by making blood and urine more alkaline or less acidic. It acts as an osmotic diuretic, increasing urine flow, urinary pH, and excretion of fixed acids, carbon dioxide, and electrolytes.
• Mechanism of Action: When administered intravenously, tromethamine acts as a proton acceptor, binding hydrogen ions and increasing bicarbonate anion levels. It also acts as an osmotic diuretic, increasing urine flow and excretion of acids and electrolytes.
• Water Balance: Tromethamine is rapidly eliminated by the kidneys, with a significant fraction appearing in the urine. It helps maintain water balance in the body, which is essential for various physiological processes.
• Chemical Interaction and Functionalization: Tromethamine contains functional groups like amino and alcohol hydroxyl groups, which interact with graphene oxide (GO) and nitrogen-doped carbon (NC) to facilitate reduction, nitrogen doping, and functionalization of graphene. These interactions enhance the electrochemical performance of the resulting composite materials.

Technology Process of Tromethamine

There total 18 articles about Tromethamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ meloxicam trometamol salt + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1)

Guidance literature:

Reference yield: 85.0%

{NiCl2(2-(2-pyridinyl)-4,4-bis(hydroxymethyl)-2-oxazoline)2} → {Ni(H2O)2(pyridine-2-carboxylic acid)2}*2H2O + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1)

Guidance literature:

In water; reflux (50 h);; pptn.; filtration; washing (ethanol); drying (vac.); elem. anal.; evapn. of aq. filtrate; extraction (3 times/hot ethanol); cooling of filtrate yields 2-amino-2-hydroxymethyl-1,3-propanediol;;

DOI:10.1016/S0020-1693(00)85542-5

Reference yield: 10.0%

→ 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1)

Guidance literature:

upstream raw materials:

2-hydroxymethyl-2-nitro-propane-1,3-diol

Protonated tris(hydroxymethyl)aminoamethane

C₁₄H₁₃NO

2-propenamide

Downstream raw materials:

N-Phenyl-N'-[1,1-bis-hydroxymethyl-2-hydroxyethyl]-urea

N-[tris(hydroxymethyl)methyl]octadecamide

2-phenyl-4(bis-hydroxymethyl)-Δ²-oxazoline

(4a,6a-dimethyl-tetrahydro-1,4-dioxa-6b-aza-cyclopenta[cd]pentalen-2a-yl)-methanol

Refernces

• 1、 Vega, Carmen A.,Vila, Pablo. "Thermodynamics of the hydrolysis of TRISH+ in (water + 10 or + 20 mass per cent of acetonitrile) from 263.15 to 298.15 K". . p. 385 - 390. Retrieved 1987.
• 2、 -. "COMPOSITION FOR STERILIZATION AND CLEANING, METHOD FOR PRODUCING SAME, AND STERILIZATION AND CLEANING METHOD EMPLOYING SAME". . . Retrieved 2022/01/08.
• 3、 -. "PROTEIN STERILISATION BY RADIATION AND ADDITION OF A STABILISING COMPOSITION". . . Retrieved 2010/03/02.