2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester

Base Information

Chemical Name:2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester
CAS No.:894094-68-9
Molecular Formula:C₂₅H₂₇NO₆S
Molecular Weight:469.558
Hs Code.:

Synonyms:2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester

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Chemical Property of 2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester

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Technology Process of 2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester

There total 3 articles about 2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 894094-67-8
2-(4-benzenesulfonyloxy-benzyl)-2-(tert-butoxycarbonyl-methylamino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

: 894094-68-9
2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tetlet.2006.03.024

Reference yield:

: 5398-09-4
4-tolyl benzenesulfonate

: 894094-68-9
2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 4 h / Heating

2.1: diisopropyl amine; n-BuLi / tetrahydrofuran / 1 h / -78 °C

2.2: 59 percent / tetrahydrofuran / 3 h / -78 °C

3.1: 73 percent / TFA / CH₂Cl₂ / 0 - 20 °C

With N-Bromosuccinimide; n-butyllithium; diisopropylamine; trifluoroacetic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1016/j.tetlet.2006.03.024

Reference yield:

: 1836-70-0
benzenesulfonic acid 4-bromomethyl-phenyl ester

: 894094-68-9
2-(4-benzenesulfonyloxy)benzyl-3-(4-methoxy-phenyl)-2-methylaminopropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropyl amine; n-BuLi / tetrahydrofuran / 1 h / -78 °C

1.2: 59 percent / tetrahydrofuran / 3 h / -78 °C

2.1: 73 percent / TFA / CH₂Cl₂ / 0 - 20 °C

With n-butyllithium; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2006.03.024