(4R^,5S^)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

Base Information

Chemical Name:(4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid
CAS No.:122358-34-3
Molecular Formula:C₁₂H₁₆O₃
Molecular Weight:208.257
Hs Code.:

(4R<sup>*</sup>,5S<sup>*</sup>)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

Synonyms:(4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

Suppliers and Price of (4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of (4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

There total 7 articles about (4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1504-55-8,39924-63-5,55131-20-9
(E)-3-phenyl-2-methyl-2-propenol

: 122358-34-3
(4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / 1.) VO(acac)2, 70percent aq. t-butylhydroperoxide / benzene / 1 h / 80 °C

2: 1.) oxalyl chloride, dmso, 2.) Et₃N / 1.) CH₂Cl₂, -50 deg C, 1 h, 2.) room temp., 15 min

3: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) 30 min

4: formic acid, Et₃N / Pd₂(dba)CHCl₃-n-Bu₃P / benzene / Ambient temperature; other solvents

5: H₂ / 5percent Pd/C / ethyl acetate / 10 h / Ambient temperature

6: 10percent aq. NaOH / diethyl ether / 8 h / Ambient temperature

With tert.-butylhydroperoxide; sodium hydroxide; formic acid; oxalyl dichloride; bis(acetylacetonate)oxovanadium; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; tributylphosphine; Pd₂(dba)(CHCl₃); In diethyl ether; ethyl acetate; benzene;
DOI:10.1021/ja00198a045

Reference yield:

: 129313-31-1
(+/-)-(2S^*,3S^*)-2,3-Epoxy-2-methyl-3-phenylpropan-1-ol

: 122358-34-3
(4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) oxalyl chloride, dmso, 2.) Et₃N / 1.) CH₂Cl₂, -50 deg C, 1 h, 2.) room temp., 15 min

2: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) 30 min

3: formic acid, Et₃N / Pd₂(dba)CHCl₃-n-Bu₃P / benzene / Ambient temperature; other solvents

4: H₂ / 5percent Pd/C / ethyl acetate / 10 h / Ambient temperature

5: 10percent aq. NaOH / diethyl ether / 8 h / Ambient temperature

With sodium hydroxide; formic acid; oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; tributylphosphine; Pd₂(dba)(CHCl₃); In diethyl ether; ethyl acetate; benzene;
DOI:10.1021/ja00198a045

Reference yield:

: 343771-16-4
(+/-)-(2R^*,3S^*)-2,3-Epoxy-2-methyl-3-phenylpropanal

: 122358-34-3
(4R^*,5S^*)-5-Hydroxy-4-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) 30 min

2: formic acid, Et₃N / Pd₂(dba)CHCl₃-n-Bu₃P / benzene / Ambient temperature; other solvents

3: H₂ / 5percent Pd/C / ethyl acetate / 10 h / Ambient temperature

4: 10percent aq. NaOH / diethyl ether / 8 h / Ambient temperature

With sodium hydroxide; formic acid; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; tributylphosphine; Pd₂(dba)(CHCl₃); In diethyl ether; ethyl acetate; benzene;
DOI:10.1021/ja00198a045