C₁₉H₁₇FN₄O₂S

Base Information

• Chemical Name: C₁₉H₁₇FN₄O₂S
• CAS No.: 1349902-21-1
• Molecular Formula: C₁₉H₁₇FN₄O₂S
• Molecular Weight: 384.434
• Mol file: 1349902-21-1.mol

Synonyms:C₁₉H₁₇FN₄O₂S

Chemical Property of C₁₉H₁₇FN₄O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₉H₁₇FN₄O₂S

There total 3 articles about C₁₉H₁₇FN₄O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}acetic acid (356058-42-9) → C19H17FN4O2S (1349902-21-1)

Guidance literature:

With 1,1'-carbonyldiimidazole; In isobutyl methyl ether; at 70 ℃; Industry scale; Inert atmosphere;

Reference yield:

methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → C19H17FN4O2S (1349902-21-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1-methyl-pyrrolidin-2-one / 2.75 h / 60 °C / Inert atmosphere

2.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; water / 4.5 h / 20 - 123 °C / Inert atmosphere

3.1: sodium hydroxide; sodium carbonate / isopropyl alcohol; water / 2.5 h / 40 °C

3.2: 2.5 h / 20 °C

4.1: 1,1'-carbonyldiimidazole / isobutyl methyl ether / 70 °C / Industry scale; Inert atmosphere

With chloro-trimethyl-silane; sodium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; isobutyl methyl ether; water; isopropyl alcohol;

Reference yield:

sodium ({2-[(methyloxy)carbonyl]-1-cyclopenten-1-yl}amino)acetate (1349902-19-7) → C19H17FN4O2S (1349902-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; water / 4.5 h / 20 - 123 °C / Inert atmosphere

2.1: sodium hydroxide; sodium carbonate / isopropyl alcohol; water / 2.5 h / 40 °C

2.2: 2.5 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / isobutyl methyl ether / 70 °C / Industry scale; Inert atmosphere

With chloro-trimethyl-silane; sodium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; isobutyl methyl ether; water; isopropyl alcohol;

upstream raw materials:

methyl 2-oxocyclopentane-1-carboxylate

{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}acetic acid

sodium ({2-[(methyloxy)carbonyl]-1-cyclopenten-1-yl}amino)acetate

Downstream raw materials:

N-[2-(diethylamino)ethyl]-2-(2-{[(4-fluorophenyl)methyl]thio}-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-{[4’-(trifluoromethyl)-4-biphenylyl]methyl}acetamide