(2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane

Base Information

• Chemical Name: (2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane
• CAS No.: 853055-36-4
• Molecular Formula: C₆₈H₈₉NO₁₀
• Molecular Weight: 1080.46
• Mol file: 853055-36-4.mol

Synonyms:(2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane

Chemical Property of (2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane

There total 9 articles about (2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S,3S,4R)-2-azido-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane (853055-34-2) → (2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane (853055-36-4)

Guidance literature:

With pyridine; sodium sulfide; sulfuric acid; at 20 ℃; for 16h;

DOI:10.1021/ol050659f

Reference yield: 93.0%

→ (2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane (853055-36-4)

Guidance literature:

Reference yield:

(2S,3S,4R)-2-azido-3,4-di-O-(p-methoxybenzyl)octadecan-1-ol (853055-32-0) → (2S,3S,4R)-2-amino-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane (853055-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 mg / 4 Angstroem molecular sieves; TBAI; DIPEA / benzene / 1.5 h / 65 °C

2: 93 percent / Na₂S; aq. H₂SO₄; pyridine / 16 h / 20 °C

With pyridine; sodium sulfide; 4 A molecular sieve; sulfuric acid; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In benzene;

DOI:10.1021/ol050659f

upstream raw materials:

(2S,3S,4R)-2-azido-3,4-di-O-para-methoxybenzyl-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-octadecane

(2S,3S,4R)-2-azido-3,4-di-O-(p-methoxybenzyl)octadecan-1-ol

2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl iodide

D-ribo-phytosphingosine

Downstream raw materials:

C₉₁H₁₃₄N₂O₁₁

C₉₃H₁₃₈N₂O₁₁

C₉₅H₁₄₂N₂O₁₁

C₁₀₁H₁₅₄N₂O₁₁