(2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran

Base Information

• Chemical Name: (2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran
• CAS No.: 625078-97-9
• Molecular Formula: C₁₅H₁₈F₃NO₅
• Molecular Weight: 349.307
• Mol file: 625078-97-9.mol

Synonyms:(2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran

Chemical Property of (2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran

There total 1 articles about (2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ C15H18F3NO5 + (2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran (625078-97-9)

Guidance literature:

Reference yield:

(2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran (625078-97-9) → (R)-2-((2R,6S)-6-Methyl-tetrahydro-pyran-2-yloxy)-2-(4-trifluoromethoxy-phenyl)-ethylamine

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; methanol; at 0 ℃;

DOI:10.1002/anie.200352007

Reference yield:

(2S,6R)-2-Methyl-6-[(R)-2-nitro-1-(4-trifluoromethoxy-phenyl)-ethoxy]-tetrahydro-pyran (625078-97-9) → [2-hydroxy-2-(4-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: NiCl₂*6H₂O; NaBH₄ / methanol; tetrahydrofuran / 0 °C

2: methanol; tetrahydrofuran / 0 - 20 °C

3: 84 percent / MPTsOH II / methanol / 20 °C

With sodium tetrahydroborate; MPTsOH II; nickel dichloride; In tetrahydrofuran; methanol;

DOI:10.1002/anie.200352007

Downstream raw materials:

[(R)-2-((2R,6S)-6-Methyl-tetrahydro-pyran-2-yloxy)-2-(4-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester