3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Base Information

• Chemical Name: 3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide
• CAS No.: 698355-42-9
• Molecular Formula: C₂₂H₂₈N₂O₂S₃
• Molecular Weight: 448.675

Synonyms:3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Chemical Property of 3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Chemical Property:

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Technology Process of 3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

There total 2 articles about 3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(4-bromobenzyl)-thiazole (698355-37-2) + 5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid (163520-14-7) → 3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide (698355-42-9)

Guidance literature:

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; for 2h; Heating / reflux;

Reference yield: 60.0%

2-(4-bromobenzyl)-thiazole (698355-37-2) + C18H26BNO4S2 → 3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide (698355-42-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide; In ethanol; toluene; for 2h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2010.03.064

Reference yield:

3-[4-(thiazole-2-yl-methyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide (698355-42-9) → 3-(4-thiazol-2-ylmethylphenyl)-5-isobutyl-2-sulfonamide

Guidance literature:

With boron trichloride; In hexane; dichloromethane; at 20 ℃; for 0.666667h;

upstream raw materials:

2-(4-bromobenzyl)-thiazole

5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

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