(5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Base Information

Chemical Name:(5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]
CAS No.:1258684-29-5
Molecular Formula:C₂₂H₃₀N₂O₃
Molecular Weight:370.492
Hs Code.:

Synonyms:(5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

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Chemical Property of (5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

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Technology Process of (5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

There total 4 articles about (5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: C₂₄H₃₁F₃N₂O₅

: 1258684-29-5
(5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: With potassium carbonate; In methanol; water; at 25 ℃; for 2h;
DOI:10.1002/cjoc.201090290

Reference yield:

: 1258684-48-8
2-[11-(benzylmethylamino)-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-9-yl]-3-(4-methoxyphenyl)-propan-1-ol

: 1258684-29-5
(5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: Multi-step reaction with 3 steps

1.1: 20% palladium(II) hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 759.83 Torr

2.1: dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C

2.2: 0.5 h / -78 °C

2.3: -78 - 0 °C

3.1: potassium carbonate / methanol; water / 2 h / 25 °C

With 20% palladium(II) hydroxide on carbon; hydrogen; potassium carbonate; dimethyl sulfoxide; In methanol; dichloromethane; water;
DOI:10.1002/cjoc.201090290

Reference yield:

: C₃₅H₅₄N₂O₄Si

: 1258684-29-5
(5S)-4-methyl-2-[(4-methoxyphenyl)methyl]-dispiro-[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

2.1: 20% palladium(II) hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 759.83 Torr

3.1: dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C

3.2: 0.5 h / -78 °C

3.3: -78 - 0 °C

4.1: potassium carbonate / methanol; water / 2 h / 25 °C

With 20% palladium(II) hydroxide on carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dimethyl sulfoxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/cjoc.201090290