N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide

Base Information

• Chemical Name: N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide
• CAS No.: 1084333-31-2
• Molecular Formula: C₁₅H₁₃F₂N₃O₃S
• Molecular Weight: 353.349
• Mol file: 1084333-31-2.mol

Synonyms:N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide

Chemical Property of N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide

There total 1 articles about N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N'-(3-hydroxyphenyl)-N,N-dimethyl-sulfamide (539807-29-9) + 2,4,6-trifluorobenzonitrile (96606-37-0,103498-69-7) → N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide (1084333-31-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide (1084333-31-2) + 2-fluro-4-iodoaniline (29632-74-4) → N'-[3-[2-cyano-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy]phenyl]-N,N-dimethyl-sulfamide (1084331-90-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -60 - 20 ℃; for 22.5h;

Reference yield:

N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide (1084333-31-2) + 2-fluro-4-iodoaniline (29632-74-4) → 2-[3-[[(dimethylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide (1084332-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 22.5 h / -60 - 20 °C

2.1: sodium hydroxide / water; dimethyl sulfoxide

2.2: 21.5 h / 20 - 65 °C

With sodium hydroxide; potassium tert-butylate; In tetrahydrofuran; water; dimethyl sulfoxide;

upstream raw materials:

N'-(3-hydroxyphenyl)-N,N-dimethyl-sulfamide

2,4,6-trifluorobenzonitrile

Downstream raw materials:

N'-[3-[2-cyano-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy]phenyl]-N,N-dimethyl-sulfamide

2-[3-[[(dimethylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide