(5R)-methylcyclohex-1-enyl p-toluenesulfonylazine

Base Information

• Chemical Name: (5R)-methylcyclohex-1-enyl p-toluenesulfonylazine
• CAS No.: 78939-24-9
• Molecular Formula: C₁₄H₁₈N₂O₂S
• Molecular Weight: 278.375
• Mol file: 78939-24-9.mol

Synonyms:(5R)-methylcyclohex-1-enyl p-toluenesulfonylazine

Chemical Property of (5R)-methylcyclohex-1-enyl p-toluenesulfonylazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R)-methylcyclohex-1-enyl p-toluenesulfonylazine

There total 3 articles about (5R)-methylcyclohex-1-enyl p-toluenesulfonylazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(-)-trans-(2R)-bromo-(5R)-methylcyclohexanone p-toluenesulfonylhydrazone (78939-23-8) → (5R)-methylcyclohex-1-enyl p-toluenesulfonylazine (78939-24-9)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; water; at 0 ℃; for 0.0833333h;

DOI:10.1021/ja00408a007

Reference yield:

(-)-trans-(2R)-bromo-(5R)-methylcyclohexanone (18951-83-2) → (5R)-methylcyclohex-1-enyl p-toluenesulfonylazine (78939-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl ether

2: 91 percent / NaHCO₃ / diethyl ether; H₂O / 0.08 h / 0 °C

With sodium hydrogencarbonate; In diethyl ether; water;

DOI:10.1021/ja00408a007

Reference yield:

toluene-4-sulfonic acid hydrazide (1576-35-8) → (5R)-methylcyclohex-1-enyl p-toluenesulfonylazine (78939-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl ether

2: 91 percent / NaHCO₃ / diethyl ether; H₂O / 0.08 h / 0 °C

With sodium hydrogencarbonate; In diethyl ether; water;

DOI:10.1021/ja00408a007

upstream raw materials:

(-)-trans-(2R)-bromo-(5R)-methylcyclohexanone p-toluenesulfonylhydrazone

(-)-trans-(2R)-bromo-(5R)-methylcyclohexanone

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

(-)-(5R)-methylcyclohex-2-enone p-toluenesulfonylhydrazone

(+)-(5R)-methyl-1,3-cyclohexadiene

(+)-(5R)-methyl-3-deuterio-1,3-cyclohexadiene