[2R-(2R)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)pent-4-enyl)piperidinecarboxylate

Base Information

Chemical Name:[2R-(2R)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)pent-4-enyl)piperidinecarboxylate
CAS No.:251995-44-5
Molecular Formula:C₂₂H₂₈N₂O₄
Molecular Weight:384.475
Hs Code.:

Synonyms:[2R-(2R)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)pent-4-enyl)piperidinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2R-(2R)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)pent-4-enyl)piperidinecarboxylate

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Technology Process of [2R-(2R)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)pent-4-enyl)piperidinecarboxylate

There total 2 articles about [2R-(2R)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)pent-4-enyl)piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 123-56-8,89963-74-6
Succinimide

: 251995-42-3
[2R-(2S)]-phenylmethyl 2-(2-hydroxypent-4-enyl)piperidinecarboxylate

: 251995-44-5
[2R-(2R)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)pent-4-enyl)piperidinecarboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at -20 - 0 ℃; for 4h;
DOI:10.1021/jo991034w

Reference yield:

: 190383-58-5
[2R-(2R)]-1-benzyloxycarbonyl-2-(2,3-epoxypropyl)piperidine

: 251995-44-5
[2R-(2R)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)pent-4-enyl)piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / CuBr; Me₂S / tetrahydrofuran / -78 - -30 °C

2: 70 percent / Ph₃P; DEAD / tetrahydrofuran / 4 h / -20 - 0 °C

With dimethylsulfide; triphenylphosphine; copper(I) bromide; diethylazodicarboxylate; In tetrahydrofuran; 1: Addition / 2: Mitsunobu reaction;
DOI:10.1021/jo991034w