trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one

Base Information

Chemical Name:trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one
CAS No.:155624-52-5
Molecular Formula:C₁₉H₂₇F₃O₂Si
Molecular Weight:372.503
Hs Code.:

Synonyms:trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one

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Chemical Property of trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one

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Technology Process of trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one

There total 5 articles about trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-ol

: 155624-52-5
trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 2.5h; Ambient temperature;
DOI:10.1021/jo00084a009

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 155624-52-5
trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent

2: 2,6-lutidine / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) r.t, 15 min

3: 90 percent / BuLi, BF₃*Et₂O

4: 87 percent / LAH / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) reflux, 8 h

5: 65 percent / Dess-Martin periodinane / CH₂Cl₂ / 2.5 h / Ambient temperature

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; n-butyllithium; boron trifluoride diethyl etherate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00084a009

Reference yield:

: 99902-35-9,130325-02-9,67648-04-8
5-phenylpent-1-yn-3-ol

: 155624-52-5
trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-lutidine / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) r.t, 15 min

2: 90 percent / BuLi, BF₃*Et₂O

3: 87 percent / LAH / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) reflux, 8 h

4: 65 percent / Dess-Martin periodinane / CH₂Cl₂ / 2.5 h / Ambient temperature

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; n-butyllithium; boron trifluoride diethyl etherate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00084a009