(S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone

Base Information

Chemical Name:(S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone
CAS No.:1255908-99-6
Molecular Formula:C₁₈H₁₈N₂O₈S₂
Molecular Weight:454.482
Hs Code.:

Synonyms:(S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone

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Chemical Property of (S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone

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Technology Process of (S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone

There total 9 articles about (S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 608141-42-0
(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

: 932032-16-1
4-nitrothiophene[3,4-c]furan-1,3-diketone

: 1255908-99-6
(S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone

Guidance literature:: (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine; 4-nitrothiophene[3,4-c]furan-1,3-diketone; In tetrahydrofuran; at 20 ℃; for 16h;

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 3h; Reflux;

Reference yield:

: 6007-85-8
1H,3H-thieno[3,4-c]furan-1,3-dione

: 1255908-99-6
(S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitric acid / 2 h / 0 - 20 °C

2.1: acetic anhydride / 3 h / 140 °C

3.1: tetrahydrofuran / 16 h / 20 °C

3.2: 3 h / Reflux

With nitric acid; acetic anhydride; In tetrahydrofuran;

Reference yield:

: 4282-29-5
thiophene-3,4-dicarboxylic acid

: 1255908-99-6
(S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride / 16 h / 110 °C

2.1: nitric acid / 2 h / 0 - 20 °C

3.1: acetic anhydride / 3 h / 140 °C

4.1: tetrahydrofuran / 16 h / 20 °C

4.2: 3 h / Reflux

With nitric acid; acetic anhydride; In tetrahydrofuran;