2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine

Base Information

Chemical Name:2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine
CAS No.:1421867-93-7
Molecular Formula:C₃₂H₄₇BrN₂O₂Si₂
Molecular Weight:627.812
Hs Code.:

Synonyms:2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine

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Chemical Property of 2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine

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Technology Process of 2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine

There total 1 articles about 2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201908-84-0
(2,2'-(2,5-dibromo-1,4-phenylene)bis(ethane-2,1-diyl))bis(oxy)bis(tert-butyldimethylsilane)

: 1421867-93-7
2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 24 h / Inert atmosphere; Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 24 h / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; ethanol; toluene; 2.1: |Negishi Coupling / 3.1: |Suzuki Coupling;
DOI:10.1039/c3ta01226c

Reference yield: 58.7%

: 1421867-93-7
2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine

: 196212-27-8
4,4,5,5-tetramethyl-2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,3,2-dioxaborolane

: 1423631-52-0
1,3-bis(6-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}pyridin-3-yl)benzene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 85 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c3ta01226c

Reference yield: 53.4%

: 4,7-bis-pinacolato-diborane-2,1,3-benzothiadiazole

: 1421867-93-7
2-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}-5-bromopyridine

: 1423631-51-9
4,7-bis(6-{2,5-bis[2-(tert-butyldimethylsilanyloxy)ethyl]-4-pyridin-2-ylphenyl}pyridin-3-yl)benzo[1,2,5]thiadiazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 85 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c3ta01226c