4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Base Information

Chemical Name:4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide
CAS No.:1436424-66-6
Molecular Formula:C₂₈H₃₂ClF₅N₆O₂
Molecular Weight:615.046
Hs Code.:

Synonyms:4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

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Chemical Property of 4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

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Technology Process of 4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

There total 13 articles about 4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,5-diazabicyclo[2.2.1]heptane dihydrobromide

: C₂₃H₂₃Cl₂F₅N₄O₂

: 1436424-66-6
4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 1436424-66-6
4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 12 h

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

4: N,N-dimethyl-formamide / 1 h / 80 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436424-66-6
4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: isopropyl alcohol / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 12 h

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

7: N,N-dimethyl-formamide / 1 h / 80 °C

With hydrogenchloride; ethanol; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; isopropyl alcohol;