(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine

Base Information

Chemical Name:(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine
CAS No.:913737-81-2
Molecular Formula:C₂₂H₂₄ClNO₂
Molecular Weight:369.891
Hs Code.:

Synonyms:(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine

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Chemical Property of (1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine

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Technology Process of (1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine

There total 2 articles about (1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 913737-80-1
[(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexyl]-carbamic acid tert-butyl ester

: 913737-81-2
(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine

Guidance literature:: [(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexyl]-carbamic acid tert-butyl ester; With ethanol; toluene-4-sulfonic acid; In tetrahydrofuran; for 9h; Heating / reflux;

With sodium carbonate; In tetrahydrofuran; ethanol; water;

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 913737-81-2
(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.67 h

1.2: 16 h / 20 °C

2.1: ethanol; toluene-4-sulfonic acid / tetrahydrofuran / 9 h / Heating / reflux

With ethanol; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran;

Reference yield: 83.0%

: 50998-17-9
6-bromoquinoxaline

: 913737-81-2
(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexylamine

: 913737-82-3
[(1R,3R)-3-(3-chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexyl]-quinoxalin-6-yl-amine

Guidance literature:: With sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 1.5h;