1-{3-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-isochroman-1-yl]-propyl}-4-pyridin-2-yl-piperazine

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Chemical Name:1-{3-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-isochroman-1-yl]-propyl}-4-pyridin-2-yl-piperazine
CAS No.:145014-27-3
Molecular Formula:C₂₉H₃₄FN₃O₃
Molecular Weight:491.606
Hs Code.:

Synonyms:1-{3-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-isochroman-1-yl]-propyl}-4-pyridin-2-yl-piperazine

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Chemical Property of 1-{3-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-isochroman-1-yl]-propyl}-4-pyridin-2-yl-piperazine

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Technology Process of 1-{3-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-isochroman-1-yl]-propyl}-4-pyridin-2-yl-piperazine

There total 2 articles about 1-{3-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-isochroman-1-yl]-propyl}-4-pyridin-2-yl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 34803-66-2
1-(2-pyridyl)piperazine

: 63954-72-3
1-(4-fluorophenyl)-1-(3-chloropropyl)-6,7-dimethoxyisochroman

: 145014-27-3
1-{3-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-isochroman-1-yl]-propyl}-4-pyridin-2-yl-piperazine

Guidance literature:: In ethylene glycol; at 50 - 70 ℃; for 20h;
DOI:10.1021/jm00343a015

Reference yield:

: 7417-21-2
2-(3,4-dimethoxyphenyl)ethyl alcohol

: 145014-27-3
1-{3-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-isochroman-1-yl]-propyl}-4-pyridin-2-yl-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / BH₃*Et₂O / 22 °C

2: 41 percent / ethane-1,2-diol / 20 h / 50 - 70 °C

With tetrafluoroboric acid-diethyl ether complex; In ethylene glycol;
DOI:10.1021/jm00343a015