(S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

Base Information

Chemical Name:(S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine
CAS No.:1215867-37-0
Molecular Formula:C₂₆H₁₉FN₄O₂
Molecular Weight:438.461
Hs Code.:

Synonyms:(S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

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Chemical Property of (S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

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Technology Process of (S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

There total 4 articles about (S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.6%

: 1215867-40-5
(S)-2′-amino-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-7-yl trifluoromethanesulfonate

: 174669-73-9
(2-fluoro-pyridin-3-yl)boronic acid

: 1215867-37-0
(S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 2h; Inert atmosphere; Sealed vial;

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1215867-37-0
(S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.83 h / 80 °C / Inert atmosphere; Sealed vial

2: triethylamine / dichloromethane / 4 h

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere; Sealed vial

With potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 1: Suzuki Coupling / 3: Suzuki Coupling;

Reference yield:

: 1215867-38-1
(S)-2'-amino-3-bromo-5'H-spiro[chromeno[2,3-b]pyridin-5,4'-oxazol]-7-ol

: 1215867-37-0
(S)-7-(2-fluoropyridin-3-yl)-3-(p-tolyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.83 h / 80 °C / Inert atmosphere; Sealed vial

2: triethylamine / dichloromethane / 4 h

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere; Sealed vial

With potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 1: Suzuki Coupling / 3: Suzuki Coupling;