[4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone

Base Information

Chemical Name:[4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone
CAS No.:1357456-40-6
Molecular Formula:C₃₂H₃₉N₅O₂S
Molecular Weight:557.76
Hs Code.:

Synonyms:[4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone

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Chemical Property of [4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone

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Technology Process of [4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone

There total 6 articles about [4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357456-67-7
C₂₂H₂₄N₄O₂S

: 30568-44-6
2-[4-(methyloxy)phenyl]-2-propanamine

: 1357456-40-6
[4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone

: C₃₂H₃₉N₅O₂S

Guidance literature:: With acetic acid; In methanol; 1,2-dichloro-ethane; at 20 - 55 ℃; optical yield given as %de;
DOI:10.1016/j.bmcl.2011.11.126

Reference yield:

: 1185310-36-4
C₁₁H₁₄N₄*ClH

: 1357456-40-6
[4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone

: C₃₂H₃₉N₅O₂S

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: acetic acid / methanol; 1,2-dichloro-ethane / 20 - 55 °C

With benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.11.126

Reference yield:

: 1357456-75-7
(2E)-3-(thiophen-3-yl)prop-2-enoate

: 1357456-40-6
[4-(1H-benzimidazol-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[2-(4-methoxyphenyl)propan-2-yl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone

: C₃₂H₃₉N₅O₂S

Guidance literature:: Multi-step reaction with 4 steps

1: hydroquinone / toluene / 24 h / 170 °C

2: water; lithium hydroxide / tetrahydrofuran / 2 h / 60 °C

3: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4: acetic acid / methanol; 1,2-dichloro-ethane / 20 - 55 °C

With water; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; hydroquinone; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; toluene; 1: Diels-Alder reaction;
DOI:10.1016/j.bmcl.2011.11.126