(Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester

Base Information

Chemical Name:(Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester
CAS No.:133931-14-3
Molecular Formula:C₂₄H₂₄INO₄
Molecular Weight:517.363
Hs Code.:

Synonyms:(Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester

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Chemical Property of (Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester

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Technology Process of (Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester

There total 3 articles about (Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 133931-13-2
1-benzyl-4-iodo-3-methyleneindoline

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 133931-14-3
(Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester

Guidance literature:: In toluene; at 85 ℃;

Reference yield:

: 133931-11-0
N-allyl-N-benzyl-2-bromoaniline

: 133931-14-3
(Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Cp₂Zr(Me)Cl, t-BuLi, 2.) I₂ / 1.) THF, from -78 deg C to RT, 2.) CH₂Cl₂

2: 100 percent / DBU / toluene / 65 °C

3: 53 percent / toluene / 85 °C

With zirconocene methyl chloride; iodine; tert.-butyl lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene;

Reference yield:

: 133931-12-1
1-benzyl-4-iodo-3-(iodomethyl)indoline

: 133931-14-3
(Z)-2-(1-Benzyl-4-iodo-1H-indol-3-ylmethyl)-but-2-enedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / DBU / toluene / 65 °C

2: 53 percent / toluene / 85 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene;