N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine

Base Information

• Chemical Name: N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine
• CAS No.: 944474-16-2
• Molecular Formula: C₂₇H₂₃N₃O₂
• Molecular Weight: 421.499
• Mol file: 944474-16-2.mol

Synonyms:N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine

Chemical Property of N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine

There total 4 articles about N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-(N,N-bis(4-methoxyphenyl)amino)benzoic acid (704914-80-7) + 1,2-diamino-benzene (95-54-5) → N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine (944474-16-2)

Guidance literature:

With phosphoric acid; In ethylene glycol; at 160 ℃; for 14h;

DOI:10.1021/jo070318a

Reference yield:

methyl 4-iodobenzoate (619-44-3) → N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine (944474-16-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tert-butoxide; tri-tert-butylphosphine / Pd₂(dba)3 / toluene / 7 h / 100 °C

2: 2.755 g / aq. NaOH / ethanol / 1 h / Heating

3: 40 percent / phosphoric acid / ethane-1,2-diol / 14 h / 160 °C

With sodium hydroxide; tri-tert-butyl phosphine; phosphoric acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In ethanol; ethylene glycol; toluene;

DOI:10.1021/jo070318a

Reference yield:

bis(4-methoxyphenyl)amine (101-70-2) → N-(4-(1H-benzimidazol-2-yl)phenyl)-N,N-bis(4-methoxyphenyl)amine (944474-16-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tert-butoxide; tri-tert-butylphosphine / Pd₂(dba)3 / toluene / 7 h / 100 °C

2: 2.755 g / aq. NaOH / ethanol / 1 h / Heating

3: 40 percent / phosphoric acid / ethane-1,2-diol / 14 h / 160 °C

With sodium hydroxide; tri-tert-butyl phosphine; phosphoric acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In ethanol; ethylene glycol; toluene;

DOI:10.1021/jo070318a

upstream raw materials:

4-(N,N-bis(4-methoxyphenyl)amino)benzoic acid

1,2-diamino-benzene

C₂₂H₂₁NO₄

methyl 4-iodobenzoate