2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide

Base Information

Chemical Name:2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide
CAS No.:1309192-26-4
Molecular Formula:C₂₁H₁₇ClF₃N₃O₂
Molecular Weight:435.833
Hs Code.:

Synonyms:2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide

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Chemical Property of 2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide

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Technology Process of 2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide

There total 5 articles about 2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309195-50-3
1-(1-(4-chlorophenyl)cyclobutyl)-2-diazoethanone

: 1309195-35-4
2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one

: 1309192-26-4
2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide

Guidance literature:: With silver benzoate; triethylamine; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 50921-39-6
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

: 1309192-26-4
2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

2: diethyl ether; acetonitrile; tetrahydrofuran / 4 h / 0 °C

3: triethylamine; silver benzoate / N,N-dimethyl-formamide / 2 h

With oxalyl dichloride; silver benzoate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 863602-02-2
4-(trifluoromethyl)phthalazin-1(2H)-one

: 1309192-26-4
2-[1-(4-chlorophenyl)cyclobutyl]-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h

1.2: 1 h

2.1: triethylamine; silver benzoate / N,N-dimethyl-formamide / 2 h

With potassium tert-butylate; silver benzoate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;