3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester

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Chemical Name:3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester
CAS No.:1403829-64-0
Molecular Formula:C₃₁H₄₃N₃O₆
Molecular Weight:553.699
Hs Code.:

Synonyms:3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester

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Chemical Property of 3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester

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Technology Process of 3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester

There total 7 articles about 3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155162-42-8
2S-pyrrolidin-2-yl-oxazole-4-carboxylic acid octylamide

: C₁₃H₁₅ClO₄

: 1403829-64-0
3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester

Guidance literature:: With potassium tert-butylate; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 56658-04-9
2-bromo-5-methoxybenzoyl chloride

: 1403829-64-0
3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 16 h / 20 °C

2: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / 18 h / Reflux

3: trifluoroacetic acid; triethylsilane / dichloromethane / 3 h / 20 °C / Reflux

4: hydrogen / palladium on activated charcoal / 1,4-dioxane; ethanol / 18 h / 20 °C

5: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 50 °C

6: triethylamine; potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C

With triethylsilane; oxalyl dichloride; potassium tert-butylate; hydrogen; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; palladium on activated charcoal; palladium diacetate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 22921-68-2
2-bromo-5-methoxy-benzoic acid

: 1403829-64-0
3-(2-{(S)-2-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-pyrrolidine-1-carbonyl}-4-methoxy-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 50 °C

2: tetrahydrofuran / 16 h / 20 °C

3: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / 18 h / Reflux

4: trifluoroacetic acid; triethylsilane / dichloromethane / 3 h / 20 °C / Reflux

5: hydrogen / palladium on activated charcoal / 1,4-dioxane; ethanol / 18 h / 20 °C

6: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 50 °C

7: triethylamine; potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C

With triethylsilane; oxalyl dichloride; potassium tert-butylate; hydrogen; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; palladium on activated charcoal; palladium diacetate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;