(1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde

Base Information

• Chemical Name: (1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde
• CAS No.: 637040-73-4
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.355
• Mol file: 637040-73-4.mol

Synonyms:(1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde

Chemical Property of (1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde

There total 7 articles about (1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1R)-1-phenylethyl]formamide (261729-99-1) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde (637040-73-4) + (1R,3R,4R)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-2-carbaldehyde

Guidance literature:

N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1R)-1-phenylethyl]formamide; With trifluoroacetic anhydride; In benzene; at 20 ℃; for 1h;

benzene; With trifluorormethanesulfonic acid; at 20 ℃; for 1h;

With sodium tetrahydroborate; nickel dichloride; In ethanol; at 20 ℃; for 2h;

DOI:10.1248/cpb.51.667

Reference yield: 85.0%

N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1R)-1-phenylethyl]formamide (261729-99-1) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (1R,3R)-1,3-dimethyl-4-(phenylsulfanyl)-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde (261730-13-6) + (1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde (637040-73-4)

Guidance literature:

N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1R)-1-phenylethyl]formamide; With trifluoroacetic anhydride; In benzene; at 20 ℃; for 1h;

benzene; With trifluorormethanesulfonic acid; at 20 ℃; for 1h;

DOI:10.1248/cpb.51.667

Reference yield: 79.0%

N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1R)-1-phenylethyl]formamide (261729-99-1) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (1R,3R)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde (261730-19-2) + (1R,3R,4S)-1,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde (637040-73-4)

Guidance literature:

N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1R)-1-phenylethyl]formamide; With trifluoroacetic anhydride; In benzene; at 20 ℃; for 1h;

benzene; With trifluorormethanesulfonic acid; at 20 ℃; for 1h;

With sodium tetrahydroborate; nickel dichloride; In ethanol; at 20 ℃; for 2h;

DOI:10.1248/cpb.51.667

upstream raw materials:

N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1R)-1-phenylethyl]formamide

benzene

(R)-1-phenyl-ethyl-amine

N-[(R)-1-methyl-2-phenylsulfanylethyl]-N-[(R)-1-phenylethyl]formamide