(4aα,5β,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester

Base Information

Chemical Name:(4aα,5β,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester
CAS No.:98761-60-5
Molecular Formula:C₁₈H₂₃NO₄
Molecular Weight:317.385
Hs Code.:

Synonyms:(4aα,5β,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester

Suppliers and Price of (4aα,5β,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aα,5β,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aα,5β,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester

There total 14 articles about (4aα,5β,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 77823-96-2,77833-73-9,98761-61-6,98761-63-8
(4aα,5α,8aα)-decahydroquinoline-5-carboxylic acid hydrochloride

: 77823-92-8,98761-60-5,98761-64-9
(4aα,5α,8aα)-1-(benzyloxycarbonyl)decahydroquinoline-5-carboxylic acid

Guidance literature:: With potassium carbonate; In acetone; for 4h; Ambient temperature;
DOI:10.1021/jm00139a005

Reference yield:

: 75424-56-5
methyl (E)-6-chlorohex-2-enoate

: 77823-92-8,98761-60-5,98761-64-9
(4aα,5α,8aα)-1-(benzyloxycarbonyl)decahydroquinoline-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / NaI / dimethylformamide / 70 - 80 °C

2: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 1.5 h

3: 4-tert-butylcatechol, bis(trimethylsilyl)acetamide / toluene / 14 h / 200 - 210 °C

4: 91 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2068.6 Torr / Ambient temperature

5: 83 percent / 4percent aq. NaOH / 1.5 h / Heating

6: 80 percent / conc. HCl / 5 h / Heating

7: 82 percent / K₂CO₃ / acetone / 4 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; 4-tert-Butylcatechol; hydrogen; sodium hydride; potassium carbonate; bis-(trimethylsilyl)acetamide; sodium iodide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm00139a005

Reference yield:

: 77823-74-6
(E)-6-Iod-2-hexensaeure-methylester

: 77823-92-8,98761-60-5,98761-64-9
(4aα,5α,8aα)-1-(benzyloxycarbonyl)decahydroquinoline-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 1.5 h

2: 4-tert-butylcatechol, bis(trimethylsilyl)acetamide / toluene / 14 h / 200 - 210 °C

3: 91 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2068.6 Torr / Ambient temperature

4: 83 percent / 4percent aq. NaOH / 1.5 h / Heating

5: 80 percent / conc. HCl / 5 h / Heating

6: 82 percent / K₂CO₃ / acetone / 4 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; 4-tert-Butylcatechol; hydrogen; sodium hydride; potassium carbonate; bis-(trimethylsilyl)acetamide; palladium on activated charcoal; In ethanol; acetone; toluene;
DOI:10.1021/jm00139a005