5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol

Base Information

Chemical Name:5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol
CAS No.:719272-72-7
Molecular Formula:C₂₃H₃₀F₃N₃O
Molecular Weight:421.506
Hs Code.:

Synonyms:5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol

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Chemical Property of 5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol

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Technology Process of 5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol

There total 11 articles about 5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 719274-50-7
5-(4-{5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol

: 107326-29-4
methylammonium trifluoroacetate

: 719272-72-7
5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol

Guidance literature:: With methylamine; In methanol; at 150 ℃; for 72h;

Reference yield:

: 94994-25-9
4-carbomethoxybicyclo<2.2.2>octane-1-carboxaldehyde

: 719272-72-7
5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h

3.1: potassium hydroxide; water / methanol / Heating / reflux

4.1: 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine / dichloromethane / 2 h

5.1: water; toluene-4-sulfonic acid / acetone / 1 h / Heating / reflux

6.1: sodium tetrahydroborate / methanol / 0 - 20 °C

7.1: methylamine / methanol / 72 h / 150 °C

With potassium hydroxide; sodium tetrahydroborate; water; hydrogen; potassium hexamethylsilazane; 2-chloro-1,3-dimethylimidazolinium chloride; toluene-4-sulfonic acid; triethylamine; methylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetone;

Reference yield:

: 719274-44-9
methyl 4-[(1E)-3-(2-methyl-1,3-dioxolan-2-yl)prop-1-enyl]bicyclo[2.2.2]octane-1-carboxylate

: 719272-72-7
5-(4-{1-methyl-5-[2-(trifluoromethyl)phenyl]-1-H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)pentan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h

2: potassium hydroxide; water / methanol / Heating / reflux

3: 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine / dichloromethane / 2 h

4: water; toluene-4-sulfonic acid / acetone / 1 h / Heating / reflux

5: sodium tetrahydroborate / methanol / 0 - 20 °C

6: methylamine / methanol / 72 h / 150 °C

With potassium hydroxide; sodium tetrahydroborate; water; hydrogen; 2-chloro-1,3-dimethylimidazolinium chloride; toluene-4-sulfonic acid; triethylamine; methylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; acetone;