1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol

Base Information

• Chemical Name: 1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol
• CAS No.: 90997-23-2
• Molecular Formula: C₁₆H₁₈ClNOS
• Molecular Weight: 307.844
• Mol file: 90997-23-2.mol

Synonyms:1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol

Chemical Property of 1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol

There total 1 articles about 1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ticlopidine (55142-85-3) + acetaldehyde (75-07-0,9002-91-9) → 1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol (90997-23-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; Yield given. Multistep reaction; 1.) THF, 0 deg C, 1 h, 2.) THF, RT, overnight;

Reference yield: 82.0%

1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol (90997-23-2) → 5-(2-Chloro-benzyl)-2-ethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (121347-24-8)

Guidance literature:

With sodium tetrahydroborate; trifluoroacetic acid; In dichloromethane; for 3h; Ambient temperature;

Reference yield:

1-[5-(2-Chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-2-yl]-ethanol (90997-23-2) → [4-(3-Chloro-propoxy)-phenyl]-(2-ethyl-thieno[3,2-c]pyridin-3-yl)-methanone (90997-53-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / NaBH₄, trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

2: 32 percent / SnCl₄ / CH₂Cl₂ / 20 h / Ambient temperature

3: 51 percent / 10percent Pd/C / diphenyl ether / 0.5 h / 260 °C

4: 28 percent / 48percent aq. HBr, acetic acid / 4 h / 80 °C

5: 1.) aq. NaOH / 1.) RT, 1 h, 2.) DMF, RT, 48 h

With sodium hydroxide; sodium tetrahydroborate; palladium on activated charcoal; hydrogen bromide; tin(IV) chloride; acetic acid; trifluoroacetic acid; In diphenylether; dichloromethane;

upstream raw materials:

ticlopidine

acetaldehyde

Downstream raw materials:

5-(2-Chloro-benzyl)-2-ethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

[4-(3-Chloro-propoxy)-phenyl]-(2-ethyl-thieno[3,2-c]pyridin-3-yl)-methanone

[4-(3-Bromo-propoxy)-phenyl]-(2-ethyl-thieno[3,2-c]pyridin-3-yl)-methanone

[3,5-Dibromo-4-(3-chloro-propoxy)-phenyl]-(2-ethyl-thieno[3,2-c]pyridin-3-yl)-methanone