4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

Base Information

Chemical Name:4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile
CAS No.:914497-03-3
Molecular Formula:C₁₆H₁₃ClN₄O
Molecular Weight:312.758
Hs Code.:

Synonyms:4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

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Chemical Property of 4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

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Technology Process of 4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

There total 1 articles about 4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 129872-81-7
2,4-dichloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidine

: 914497-03-3
4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

Guidance literature:: 3,5-dimethyl-4-hydroxybenzonitrile; With sodium hydride; In 1-methyl-2-pyrridone; at 20 ℃; for 0.5h;

2,4-dichloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidine; In 1-methyl-2-pyrridone; at 160 ℃; for 16h;

Reference yield:

: 914497-03-3
4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

: 4-(7-chloro-2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 48 h / 90 °C

2: N-chloro-succinimide / dichloromethane / 16 h / Heating / reflux

With N-chloro-succinimide; trifluoroacetic acid; In dichloromethane; 2,2,2-trifluoroethanol;

Reference yield:

: 914497-03-3
4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

: 4-(7-bromo-2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 48 h / 90 °C

2: N-Bromosuccinimide / dichloromethane / 16 h / Heating / reflux

With N-Bromosuccinimide; trifluoroacetic acid; In dichloromethane; 2,2,2-trifluoroethanol;