Perlapine

Base Information

Chemical Name:Perlapine
CAS No.:1977-11-3
Molecular Formula:C₁₉H₂₁N₃
Molecular Weight:291.396
Hs Code.:
European Community (EC) Number:811-429-5
NSC Number:291840
UNII:4N8UJJ27IM
DSSTox Substance ID:DTXSID1048758
Nikkaji Number:J3.693E
Wikipedia:Perlapine
Wikidata:Q27260239
NCI Thesaurus Code:C80676
ChEMBL ID:CHEMBL340801
Mol file:1977-11-3.mol

Synonyms:6-(4-methyl-1-piperazinyl)morphanthridine;6-(4-methylpiperazin-1-yl)-11H-dibenzazepine;HUF-2333;perlapine;perlapine monohydrochloride;PLP 100-127

Suppliers and Price of Perlapine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Perlapine
10mg
$ 135.00

Cayman Chemical
Perlapine ≥98%
5mg
$ 95.00

Cayman Chemical
Perlapine ≥98%
1mg
$ 45.00

Cayman Chemical
Perlapine ≥98%
10mg
$ 140.00

American Custom Chemicals Corporation
PERLAPINE 95.00%
20MG
$ 238.00

AK Scientific
Perlapine
10mg
$ 289.00

Total 9 raw suppliers

Chemical Property of Perlapine

Chemical Property:

Vapor Pressure:7.74E-08mmHg at 25°C
Melting Point:136-138°
Refractive Index:1.6080 (estimate)
Boiling Point:437°Cat760mmHg
PKA:8.00±0.20(Predicted)
Flash Point:218.1°C
PSA：18.84000
Density:1.16g/cm³
LogP:2.22790
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:291.173547683
Heavy Atom Count:22
Complexity:411

Purity/Quality:

99% ^*data from raw suppliers

Perlapine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=NC3=CC=CC=C3CC4=CC=CC=C42
Uses Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing. Perlapine displays >10,000-fold selectivity for hM3Dq over hM3. Perlapine exhibits antipsychotic activity and blocks dopamine and serotonin receptors. Perlapine is also a novel agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD).

Technology Process of Perlapine

There total 5 articles about Perlapine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1211-06-9
5,11-dihydro-6H-dibenz[b,e]azepin-6-one

: 1977-11-3
perlapine

Guidance literature:: Multi-step reaction with 2 steps

1: 10.3 g / PCl₅ / 1.5 h / 130 °C

2: 11.19 g / xylene / 5 h / Heating

With phosphorus pentachloride; In xylene;

Reference yield:

: 90-44-8
anthracen-9(10H)-one

: 1977-11-3
perlapine

Guidance literature:: Multi-step reaction with 4 steps

1: 8.5 g / NH₂OH*HCl, sodium acetate / aq. ethanol / 0.5 h / Heating

2: 1.8 g / PPA / 1 h / 95 - 100 °C

3: 10.3 g / PCl₅ / 1.5 h / 130 °C

4: 11.19 g / xylene / 5 h / Heating

With phosphorus pentachloride; hydroxylamine hydrochloride; sodium acetate; In ethanol; xylene;

Reference yield:

: 92560-84-4
anthracen-9(10H)-one oxime

: 1977-11-3
perlapine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.8 g / PPA / 1 h / 95 - 100 °C

2: 10.3 g / PCl₅ / 1.5 h / 130 °C

3: 11.19 g / xylene / 5 h / Heating

With phosphorus pentachloride; In xylene;