(3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride

Base Information

• Chemical Name: (3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride
• CAS No.: 126485-75-4
• Molecular Formula: C₁₂H₁₆INO₃*ClH
• Molecular Weight: 385.629
• Mol file: 126485-75-4.mol

Synonyms:(3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride

Chemical Property of (3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride

There total 4 articles about (3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(3-Trimethylsilanyl-phenoxy)-acetic acid 2-dimethylamino-ethyl ester (126485-63-0) → (3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride (126485-75-4)

Guidance literature:

With hydrogenchloride; N-chloro-succinimide; sodium iodide; In acetic acid; at 65 ℃; for 1h;

DOI:10.1248/cpb.37.2276

Reference yield:

m-(Trimethylsilyl)phenol (17881-95-7) → (3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride (126485-75-4)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOC₂H₅ / ethanol / 3 h / Heating

2: 2 N NaOH / 0.5 h

3: 1.) phenyl dichlorophosphate / 1.) DMF, 0-5 deg C, 5 min; 2.) CH₂Cl₂; 3. ) pyridine, 3 h, RT

4: 61 percent / 1.) N-chlorosuccinimid, NaI; 2.) HCl gas / acetic acid / 1 h / 65 °C

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; sodium ethanolate; O-phenyl phosphorodichloridate; sodium iodide; In ethanol; acetic acid;

DOI:10.1248/cpb.37.2276

Reference yield:

(3-Trimethylsilanyl-phenoxy)-acetic acid (126485-61-8) → (3-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride (126485-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) phenyl dichlorophosphate / 1.) DMF, 0-5 deg C, 5 min; 2.) CH₂Cl₂; 3. ) pyridine, 3 h, RT

2: 61 percent / 1.) N-chlorosuccinimid, NaI; 2.) HCl gas / acetic acid / 1 h / 65 °C

With hydrogenchloride; N-chloro-succinimide; O-phenyl phosphorodichloridate; sodium iodide; In acetic acid;

DOI:10.1248/cpb.37.2276

upstream raw materials:

(3-Trimethylsilanyl-phenoxy)-acetic acid 2-dimethylamino-ethyl ester

m-(Trimethylsilyl)phenol

(3-Trimethylsilanyl-phenoxy)-acetic acid