2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester

Base Information

• Chemical Name: 2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester
• CAS No.: 250717-22-7
• Molecular Formula: C₂₁H₂₄N₄O₆
• Molecular Weight: 428.445
• Mol file: 250717-22-7.mol

Synonyms:2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester

Chemical Property of 2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester

There total 2 articles about 2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester (250717-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / Et₃N / ethanol / 6 h / Heating

2: ethanol / 16 h / Heating

With triethylamine; In ethanol; 1: Substitution / 2: Condensation;

DOI:10.1002/jhet.5570360405

Reference yield:

Benzylhydrazine (555-96-4) → 2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester (250717-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / Et₃N / ethanol / 6 h / Heating

2: ethanol / 16 h / Heating

With triethylamine; In ethanol; 1: Substitution / 2: Condensation;

DOI:10.1002/jhet.5570360405

Reference yield: 100.0%

2-[benzyl-(3-nitro-pyridin-2-yl)-hydrazono]-pentanedioic acid diethyl ester (250717-22-7) → 1-benzyl-3-(2-ethoxycarbonyl-ethyl)-1,2,3,4-tetrahydro-pyrido[3,2-e][1,2,4]triazine-3-carboxylic acid ethyl ester (250717-27-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; under 760 Torr;

DOI:10.1002/jhet.5570360405

upstream raw materials:

2-Chloro-3-nitropyridine

Benzylhydrazine

Downstream raw materials:

1-benzyl-3-(2-ethoxycarbonyl-ethyl)-1,2,3,4-tetrahydro-pyrido[3,2-e][1,2,4]triazine-3-carboxylic acid ethyl ester