[9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine

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Chemical Name:[9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine
CAS No.:127454-13-1
Molecular Formula:C₅₀H₄₂FN₅O₂
Molecular Weight:763.914
Hs Code.:

Synonyms:[9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine

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Chemical Property of [9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine

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Technology Process of [9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine

There total 6 articles about [9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 127475-51-8
[9-((1R,2R,3R,4S)-2-Fluoro-4-iodomethyl-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine

: 127454-13-1
[9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine

Guidance literature:: With pyridine; DBN; at 60 ℃;
DOI:10.1039/c39900001380

Reference yield:

: 110289-21-9
(1R,2R,3R,5R)-3-(2-Amino-6-chloro-purin-9-yl)-2-fluoro-5-hydroxymethyl-cyclopentanol

: 127454-13-1
[9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / methanol / 50 °C

2: 87 percent / imidazole / dimethylformamide / 20 °C

3: 82 percent / molecular sieves / CH₂Cl₂ / 72 h / Heating

4: 85 percent / Bu₄NF / tetrahydrofuran / 20 °C

5: 92 percent / (PhO)3PMeI / tetrahydrofuran / -65 - 0 °C

6: 78 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN), pyridine / 60 °C

With pyridine; 1H-imidazole; molecular sieve; DBN; tetrabutyl ammonium fluoride; methyltriphenoxyphosphonium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c39900001380

Reference yield:

: 127454-10-8
(1R,2R,3R,5R)-3-(2-Amino-6-methoxy-purin-9-yl)-2-fluoro-5-hydroxymethyl-cyclopentanol

: 127454-13-1
[9-((1R,2R,3R)-2-Fluoro-4-methylene-3-trityloxy-cyclopentyl)-6-methoxy-9H-purin-2-yl]-trityl-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / imidazole / dimethylformamide / 20 °C

2: 82 percent / molecular sieves / CH₂Cl₂ / 72 h / Heating

3: 85 percent / Bu₄NF / tetrahydrofuran / 20 °C

4: 92 percent / (PhO)3PMeI / tetrahydrofuran / -65 - 0 °C

5: 78 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN), pyridine / 60 °C

With pyridine; 1H-imidazole; molecular sieve; DBN; tetrabutyl ammonium fluoride; methyltriphenoxyphosphonium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c39900001380