4-iodobenzaldiacetate

Base Information

• Chemical Name: 4-iodobenzaldiacetate
• CAS No.: 133746-50-6
• Molecular Formula: C₁₁H₁₁IO₄
• Molecular Weight: 334.11
• Mol file: 133746-50-6.mol

Synonyms:4-iodobenzaldiacetate

Chemical Property of 4-iodobenzaldiacetate

Chemical Property:

Purity/Quality:

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Technology Process of 4-iodobenzaldiacetate

There total 1 articles about 4-iodobenzaldiacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-tolyl iodide (624-31-7) + acetic anhydride (108-24-7) → 4-iodobenzaldiacetate (133746-50-6)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; at 0 - 10 ℃;

DOI:10.1016/S0968-0896(98)80005-9

Reference yield: 58.0%

4-iodobenzaldiacetate (133746-50-6) → p-(iodophenyl)carboxaldehyde (15164-44-0)

Guidance literature:

With sulfuric acid; In ethanol; water; for 0.5h; Heating;

DOI:10.1016/S0968-0896(98)80005-9

Reference yield:

4-iodobenzaldiacetate (133746-50-6) → 2-[2-(4-iodo-phenyl)-vinyl]-4,5-dihydro-1H-imidazole

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / conc. H₂SO₄ / ethanol; H₂O / 0.5 h / Heating

2: 55 percent / ethyl formate / 90 °C

With sulfuric acid; formic acid ethyl ester; In ethanol; water; 1: Hydrolysis / 2: Condensation;

DOI:10.1016/S0968-0896(98)80005-9

upstream raw materials:

4-tolyl iodide

acetic anhydride

Downstream raw materials:

p-(iodophenyl)carboxaldehyde