7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid

Base Information

• Chemical Name: 7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid
• CAS No.: 76049-44-0
• Molecular Formula: C₁₅H₁₇ClO₅S
• Molecular Weight: 344.816
• Mol file: 76049-44-0.mol

Synonyms:7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid

Chemical Property of 7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid

There total 4 articles about 7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-(4-Chlorphenyl)-5-hydroxy-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>-1,2-oxathiol-6-carbonsaeureethylester-1,1-dioxid (76049-42-8) → 7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid (76049-44-0)

Guidance literature:

With sodium hydroxide; In ethanol; for 1h; Heating;

DOI:10.1002/ardp.19803130908

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid (76049-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 35 percent / CH₃COONa / acetic acid / 1 h / Heating

2: 65 percent / 1.) NaOCH₃ / 1.) 80 deg C, 2 h, 2.) room temp., 2 h

3: 90 percent / 3 N NaOH / ethanol / 1 h / Heating

With sodium hydroxide; sodium methylate; sodium acetate; In ethanol; acetic acid;

DOI:10.1002/ardp.19803130908

Reference yield:

3-(4-Chlorbenzyliden)-5,5-dimethyl-1,2-oxathiolan-4-on-2,2-dioxid (76049-41-7) → 7-(4-Chlorphenyl)-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>1,2-oxathiol-5-ol-1,1-dioxid (76049-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / 1.) NaOCH₃ / 1.) 80 deg C, 2 h, 2.) room temp., 2 h

2: 90 percent / 3 N NaOH / ethanol / 1 h / Heating

With sodium hydroxide; sodium methylate; In ethanol;

DOI:10.1002/ardp.19803130908

upstream raw materials:

7-(4-Chlorphenyl)-5-hydroxy-3,3,5-trimethyl-3,5,6,7-tetrahydropyrano<3,2-c>-1,2-oxathiol-6-carbonsaeureethylester-1,1-dioxid

4-chlorobenzaldehyde

3-(4-Chlorbenzyliden)-5,5-dimethyl-1,2-oxathiolan-4-on-2,2-dioxid

5,5-dimethyl-1,2-oxathiolane-4-one 2,2-dioxide

Downstream raw materials:

7-(4-Chlorphenyl)-3,3,5-trimethyl-5-methoxy-3,5,6,7-tetrahydro-pyrano-<3,2-c>-1,2-oxathiol-1,1-dioxid

<1-(4-Chlorphenyl)-3-oxo-butyl>-5,5-dimethyl-1,2-oxathiolan-4-on-2,2-dioxid