7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline

Base Information

Chemical Name:7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline
CAS No.:1456629-66-5
Molecular Formula:C₁₉H₁₇ClFN₃O₄S
Molecular Weight:437.879
Hs Code.:

Synonyms:7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline

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Chemical Property of 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline

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Technology Process of 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline

There total 4 articles about 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 672948-16-2
7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carbohydrazide

: 98-59-9
p-toluenesulfonyl chloride

: 1456629-66-5
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline

Guidance literature:: With pyridine; In dichloromethane; ethyl acetate; for 4h; Cooling with ice;
DOI:10.1016/j.ejmech.2013.06.056

Reference yield:

: 75073-15-3
ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate

: 1456629-66-5
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: hydrazine hydrate / ethanol / 10 h / Reflux

3: pyridine / dichloromethane; ethyl acetate / 4 h / Cooling with ice

With pyridine; potassium carbonate; hydrazine hydrate; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.06.056

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 1456629-66-5
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 2 h / 125 - 130 °C

2: diphenylether / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

4: hydrazine hydrate / ethanol / 10 h / Reflux

5: pyridine / dichloromethane; ethyl acetate / 4 h / Cooling with ice

With pyridine; potassium carbonate; hydrazine hydrate; In diphenylether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.06.056