(1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene

Base Information

Chemical Name:(1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene
CAS No.:1435482-63-5
Molecular Formula:C₃₇H₆₁NO₃Si
Molecular Weight:595.982
Hs Code.:

(1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene

Synonyms:(1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene

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Chemical Property of (1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene

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Technology Process of (1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene

There total 13 articles about (1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: C₂₇H₃₇O₂PSi

: 1435482-62-4
(1R,3aR,7aR)-octahydro-1-{(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl}-7a-methyl-4-oxo-1H-indene

: 1435482-63-5
(1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene

Guidance literature:: C₂₇H₃₇O₂PSi; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(1R,3aR,7aR)-octahydro-1-{(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl}-7a-methyl-4-oxo-1H-indene; In tetrahydrofuran; at -78 ℃; for 3h; Darkness;
DOI:10.1016/j.tetlet.2013.04.019

Reference yield:

: 1435482-61-3
(1R,3aR,4S,7aR)-octahydro-1-{(1'R)-1',5'-dimethyl-5'-N-(4''-methoxy-4'',1''-dioxo-butyl)-amino-hexyl}-7a-methyl-4-triethylsilyloxy-1H-indene

: 1435482-63-5
(1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene

Guidance literature:: Multi-step reaction with 2 steps

1.1: dipyridinium dichromate / dichloromethane / 4 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 3 h / -78 °C / Darkness

With dipyridinium dichromate; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tetlet.2013.04.019

Reference yield:

: 1435482-53-3
(1R,3aR,4S,7aR)-octahydro-1-[(1’R,2’E)-1’,5’-dimethyl-5’-nitro-hex-2’-en-1’-yl]-7a-methyl-4-triethylsilyloxy-1H-indene

: 1435482-63-5
(1R,3aS,7aR)-octahydro-1-[(1'R)-1',5'-dimethyl-5'-(2’,5’-dioxo-pyrrolidinyl)-amino-hexyl]-7a-methyl-4-(E)-[2’-(Z)-{(5’S)-2’-methylen-5’-tert-butyldimethyl-silyloxy-cyclohexyliden}-ethylidene]-1H-indene

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Reflux

3.1: triethylamine / dichloromethane / 1 h / 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h

5.1: dipyridinium dichromate / dichloromethane / 4 h

6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

6.2: 3 h / -78 °C / Darkness

With lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2013.04.019