Technology Process of ethyl (1α,2β,3β)-2,3-epoxy-4-oxocyclohexaneacetate
There total 1 articles about ethyl (1α,2β,3β)-2,3-epoxy-4-oxocyclohexaneacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: imidazole / dimethylformamide
2: MCPBA / CH2Cl2 / 0 °C
3: LiNEt2 / diethyl ether / 20 h / Heating
4: 84 percent / CH3CH2COOH / o-xylene / 20 h / Heating
5: (n-Bu)4N(1+)*F(1-) / tetrahydrofuran / 2 h / Ambient temperature
6: MCPBA / CH2Cl2 / 16 h / 0 °C
7: (COCl)2, DMSO, Et3N / CH2Cl2 / -70 - 25 °C
With
1H-imidazole; oxalyl dichloride; lithium diethylamide; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
propionic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; o-xylene; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)99249-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1: n-BuLi / tetrahydrofuran / -40 degC to room temperature
2: Et3N / ethanol / 18 h / Ambient temperature
With
n-butyllithium; triethylamine;
In
tetrahydrofuran; ethanol;
DOI:10.1016/S0040-4039(00)99249-9
- Guidance literature:
-
Multi-step reaction with 3 steps
1: n-BuLi / tetrahydrofuran / -40 degC to room temperature
2: Et3N / ethanol / 18 h / Ambient temperature
3: KOH / ethanol; H2O / 6 h / Ambient temperature
With
potassium hydroxide; n-butyllithium; triethylamine;
In
tetrahydrofuran; ethanol; water;
DOI:10.1016/S0040-4039(00)99249-9
