1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:184719-32-2
Molecular Formula:C₃₃H₃₆N₂O₇
Molecular Weight:572.658
Hs Code.:

Synonyms:1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

There total 11 articles about 1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-{2-[(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

: 184719-32-2
1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 2h; Yield given;
DOI:10.1021/jo961548k

Reference yield:

: 22900-10-3,35536-75-5,36792-85-5,113890-34-9,113890-37-2,133813-23-7
2-deoxy-D-ribose

: 184719-32-2
1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 10 steps

1: 60 percent / DMAP / pyridine / 6 h / 50 °C

2: 8.08 g / NaH / tetrahydrofuran / 6 h / 5 °C

3: (CH₃)2S*BH₃ / tetrahydrofuran / Heating

4: Et₃N / tetrahydrofuran / 2 h / 25 °C

5: Et₃N / benzene / 3 h / 25 °C

6: 10percent TFA / CH₂Cl₂ / 2 h / 25 °C

7: conc. NH₄OH / 12 h / 50 °C

8: imidazole / dimethylformamide / 1 h / 25 °C

9: DMAP / benzene / 25 °C

10: 1 M n-Bu₄NF / tetrahydrofuran / 2 h / 25 °C

With 1H-imidazole; dmap; ammonium hydroxide; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo961548k

Reference yield:

: 132151-65-6
(E)-3-methoxy-2-methylacryloyl isocyanate

: 184719-32-2
1-(2-{(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / benzene / 3 h / 25 °C

2: 10percent TFA / CH₂Cl₂ / 2 h / 25 °C

3: conc. NH₄OH / 12 h / 50 °C

4: imidazole / dimethylformamide / 1 h / 25 °C

5: DMAP / benzene / 25 °C

6: 1 M n-Bu₄NF / tetrahydrofuran / 2 h / 25 °C

With 1H-imidazole; dmap; ammonium hydroxide; tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo961548k